The 49ers have nothing to play for other than pride at this point. They're facing a Lions team that has the best record in the NFC but hasn't even clinched their division yet. Detroit will be playing with a lot on the line, meaning we can expect their very best, even in a game they should have no trouble winning.

The Detroit Lions can move one step closer to tying up top spot in the National Football Conference when they travel to the San Francisco 49ers in a

No. 2 pick Jayden Daniels and the Commanders are favored by 4.5 points in the Week 17 NFL odds, over No. 8 pick Michael Penix and the Falcons. Before that, however, a pair of veteran quarterbacks in Jordan Love and Sam Darnold will face off in Packers vs.

NFL Week 17 odds, picks, predictions, TV channel, streaming information for Monday Night Football game between Detroit Lions and San Francisco 49ers.

The Detroit Lions and San Francisco 49ers will square off in a rematch of last year's NFC Championship game on Monday Night Football in Week 17 at Levi's Stadium. The Lions will be looking to improve their road record to 8-0 and overall record to 14-2.