Pope Leo’s relationship with the ascendant Catholic right in the U.S. could be a prominent issue in his papacy.

Robert Prevost’s election as pope stunned many Catholics skeptical that an American would ever be elevated to that role.

From Washington to Rome, leaders around the globe responded to the surprise election of American Cardinal Robert Francis Prevost as the next head of the Catholic Church.

This selection comes after two days of conclave in the Sistine Chapel, tying the modern record for the fastest selection of a pope.

The 133 cardinals are expected to vote again in the morning after spending the night sequestered at the Vatican residences. On Wednesday evening, black smoke poured out of the Sistine Chapel chimney indicating no pope was elected on the first ballot of the conclave.