The Los Angeles Chargers, Cincinnati Bengals and LA Rams all won on Saturday to either seal a playoff ticket or keep their ...

Jared Goff and the Detroit Lions visit Levi’s Stadium for the final home game of this injury-riddled 49ers season ...

NFL.com's Coral Smith breaks down four things to watch for when the San Francisco 49ers host the Detroit Lions on Monday night.

In other words, the 49ers’ disappointment is getting worse as the season carries on. San Francisco has already lost stars in ...

The Seahawks defeated the Bears 6-3 on Thursday Night Football to move to 9-7 on the season, then the Rams followed with a 13 ...

The Lions can clinch the top seed in the NFC by winning their final two games or with a win against the Niners if the Minnesota Vikings lose to the Green Bay Packers on Sunday. "Anytime we lose, the ...

San Francisco 49ers running back Isaac Guerendo is set to return from foot and hamstring injuries and play Monday vs. the ...

San Francisco 49ers running back Isaac Guerendo is expected to return from foot and hamstring injuries and play Monday, a ...

The playoff-eliminated San Francisco 49ers are set to host the Detroit Lions on Monday night in a rematch of last season's ...

Who are the 10 greatest San Francisco 49ers of all time? FOX Sports Research compiled the list of Niner greats.

The Lions will face a 49ers offensive line that could be starting two tackles signed off practice squads this week ...

BYU AD Tom Holmoe was once Deion Sanders’ position coach with the 49ers. Thirty years later, the two will meet again in the ...