San Francisco 49ers running back Isaac Guerendo is expected to return from foot and hamstring injuries and play Monday, a ...

The playoff-eliminated San Francisco 49ers are set to host the Detroit Lions on Monday night in a rematch of last season's ...

Who are the 10 greatest San Francisco 49ers of all time? FOX Sports Research compiled the list of Niner greats.

The Lions will face a 49ers offensive line that could be starting two tackles signed off practice squads this week ...

BYU AD Tom Holmoe was once Deion Sanders’ position coach with the 49ers. Thirty years later, the two will meet again in the ...

The element of revenge for last season’s 34-31 loss is secondary for Detroit, considering what’s on the line the last two ...

This isn't the same 49ers team the Lions lined up against 11 months ago, but Detroit is still treating it like a marquee game ...

Coach Kyle Shanahan expressed confidence in Moody on Thursday, attributing some of the struggles to a high ankle sprain he ...

The Detroit Lions (13-2) visit the San Francisco 49ers (6-9) in an NFC title game rematch on Monday that features both teams ...

The Detroit Lions will know how meaningful their matchup with the San Francisco 49ers on Monday night will carry before they ...